Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats

Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury...

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Main Authors:	Zhong, Xiaozheng, Li, Xiaoyu, Qian, Lingling, Xu, Yiming, Lu, Yan, Zhang, Jing, Li, Nan, Zhu, Xudong, Ben, Jingjing, Yang, Qing, Chen, Qi
Format:	Online
Language:	English
Published:	Editorial Department of Journal of Biomedical Research 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613731/

id	pubmed-3613731
recordtype	oai_dc
spelling	pubmed-36137312013-04-02 Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats Zhong, Xiaozheng Li, Xiaoyu Qian, Lingling Xu, Yiming Lu, Yan Zhang, Jing Li, Nan Zhu, Xudong Ben, Jingjing Yang, Qing Chen, Qi Research Paper Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. Editorial Department of Journal of Biomedical Research 2012-09 2012-06-29 /pmc/articles/PMC3613731/ /pubmed/23554770 http://dx.doi.org/10.7555/JBR.26.20110124 Text en © 2012 by the Journal of Biomedical Research. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhong, Xiaozheng Li, Xiaoyu Qian, Lingling Xu, Yiming Lu, Yan Zhang, Jing Li, Nan Zhu, Xudong Ben, Jingjing Yang, Qing Chen, Qi
spellingShingle	Zhong, Xiaozheng Li, Xiaoyu Qian, Lingling Xu, Yiming Lu, Yan Zhang, Jing Li, Nan Zhu, Xudong Ben, Jingjing Yang, Qing Chen, Qi Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
author_facet	Zhong, Xiaozheng Li, Xiaoyu Qian, Lingling Xu, Yiming Lu, Yan Zhang, Jing Li, Nan Zhu, Xudong Ben, Jingjing Yang, Qing Chen, Qi
author_sort	Zhong, Xiaozheng
title	Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
title_short	Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
title_full	Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
title_fullStr	Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
title_full_unstemmed	Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
title_sort	glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
description	Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.
publisher	Editorial Department of Journal of Biomedical Research
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613731/
_version_	1611966712857493504

Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats

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