Endocardial to Myocardial Notch-Wnt-Bmp Axis Regulates Early Heart Valve Development

Endocardial to mesenchymal transformation (EMT) is a fundamental cellular process required for heart valve formation. Notch, Wnt and Bmp pathways are known to regulate this process. To further address how these pathways coordinate in the process, we specifically disrupted Notch1 or Jagged1 in the en...

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Bibliographic Details
Main Authors: Wang, Yidong, Wu, Bingruo, Chamberlain, Alyssa A., Lui, Wendy, Koirala, Pratistha, Susztak, Katalin, Klein, Diana, Taylor, Verdon, Zhou, Bin
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613384/