Nuclear Phosphoinositide-Specific Phospholipase C β1 Controls Cytoplasmic CCL2 mRNA Levels in HIV-1 gp120-Stimulated Primary Human Macrophages

Nuclear Phosphoinositide-Specific Phospholipase C β1 Controls Cytoplasmic CCL2 mRNA Levels in HIV-1 gp120-Stimulated Primary Human Macrophages

HIV-1 envelope glycoprotein gp120 induces, independently of infection, the release of CCL2 from macrophages. In turn, this chemokine acts as an autocrine factor enhancing viral replication. In this study, we show for the first time that phosphoinositide-specific phospholipase C (PI-PLC) is required...

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Bibliographic Details
Main Authors: Spadaro, Francesca, Cecchetti, Serena, Purificato, Cristina, Sabbatucci, Michela, Podo, Franca, Ramoni, Carlo, Gessani, Sandra, Fantuzzi, Laura
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610878/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610878/

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