Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs

Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs

The development of multicellular organisms relies on interconnected genetic programs that control progression through their life cycle. MicroRNAs (miRNAs) and transcription factors (TFs) play key roles in such regulatory circuits. Here, we describe how three evolutionary conserved miRNA-TF pairs int...

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Main Authors: Rubio-Somoza, Ignacio, Weigel, Detlef
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610633/
id pubmed-3610633
recordtype oai_dc
spelling pubmed-36106332013-04-03 Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs Rubio-Somoza, Ignacio Weigel, Detlef Research Article The development of multicellular organisms relies on interconnected genetic programs that control progression through their life cycle. MicroRNAs (miRNAs) and transcription factors (TFs) play key roles in such regulatory circuits. Here, we describe how three evolutionary conserved miRNA-TF pairs interact to form multiple checkpoints during reproductive development of Arabidopsis thaliana. Genetic, cellular, and physiological experiments show that miR159- and miR319-regulated MYB and TCP transcription factors pattern the expression of miR167 family members and their ARF6/8 targets. Coordinated action of these miRNA-TF pairs is crucial for the execution of consecutive hormone-dependent transitions during flower maturation. Cross-regulation includes both cis- and trans-regulatory interactions between these miRNAs and their targets. Our observations reveal how different miRNA-TF pairs can be organized into modules that coordinate successive steps in the plant life cycle. Public Library of Science 2013-03-28 /pmc/articles/PMC3610633/ /pubmed/23555288 http://dx.doi.org/10.1371/journal.pgen.1003374 Text en © 2013 Rubio-Somoza, Weigel http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rubio-Somoza, Ignacio
Weigel, Detlef
spellingShingle Rubio-Somoza, Ignacio
Weigel, Detlef
Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
author_facet Rubio-Somoza, Ignacio
Weigel, Detlef
author_sort Rubio-Somoza, Ignacio
title Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
title_short Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
title_full Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
title_fullStr Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
title_full_unstemmed Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
title_sort coordination of flower maturation by a regulatory circuit of three micrornas
description The development of multicellular organisms relies on interconnected genetic programs that control progression through their life cycle. MicroRNAs (miRNAs) and transcription factors (TFs) play key roles in such regulatory circuits. Here, we describe how three evolutionary conserved miRNA-TF pairs interact to form multiple checkpoints during reproductive development of Arabidopsis thaliana. Genetic, cellular, and physiological experiments show that miR159- and miR319-regulated MYB and TCP transcription factors pattern the expression of miR167 family members and their ARF6/8 targets. Coordinated action of these miRNA-TF pairs is crucial for the execution of consecutive hormone-dependent transitions during flower maturation. Cross-regulation includes both cis- and trans-regulatory interactions between these miRNAs and their targets. Our observations reveal how different miRNA-TF pairs can be organized into modules that coordinate successive steps in the plant life cycle.
publisher Public Library of Science
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610633/
_version_ 1611966022353420288

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