PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens

Our increased understanding of host pathogen interactions shows that pathogens could capitalize on host cell pathways to favor entry and disease establishment. One such pathway used by Leishmania mexicana to enter into neutrophils and macrophages is the PI3Kγ signaling pathway. We recently showed th...

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Bibliographic Details
Main Authors: Oghumu, Steve, Satoskar, Abhay R.
Format: Online
Language:English
Published: Landes Bioscience 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609848/