Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory

The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on...

Full description

Bibliographic Details
Main Authors:	Yang, Chang, Liu, Jian-Feng, Chai, Bai-Sheng, Fang, Qin, Chai, Ning, Zhao, Li-Yan, Xue, Yan-Xue, Luo, Yi-Xiao, Jian, Min, Han, Ying, Shi, Hai-Shui, Lu, Lin, Wu, Ping, Wang, Ji-Shi
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609809/

id	pubmed-3609809
recordtype	oai_dc
spelling	pubmed-36098092013-03-29 Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory Yang, Chang Liu, Jian-Feng Chai, Bai-Sheng Fang, Qin Chai, Ning Zhao, Li-Yan Xue, Yan-Xue Luo, Yi-Xiao Jian, Min Han, Ying Shi, Hai-Shui Lu, Lin Wu, Ping Wang, Ji-Shi Research Article The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM) formation (tested 24 h later), but the effects of stress on the persistence of LTM (tested at least 1 week later) are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress) during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h) after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h) after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system. Public Library of Science 2013-03-27 /pmc/articles/PMC3609809/ /pubmed/23544051 http://dx.doi.org/10.1371/journal.pone.0059075 Text en © 2013 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Chang Liu, Jian-Feng Chai, Bai-Sheng Fang, Qin Chai, Ning Zhao, Li-Yan Xue, Yan-Xue Luo, Yi-Xiao Jian, Min Han, Ying Shi, Hai-Shui Lu, Lin Wu, Ping Wang, Ji-Shi
spellingShingle	Yang, Chang Liu, Jian-Feng Chai, Bai-Sheng Fang, Qin Chai, Ning Zhao, Li-Yan Xue, Yan-Xue Luo, Yi-Xiao Jian, Min Han, Ying Shi, Hai-Shui Lu, Lin Wu, Ping Wang, Ji-Shi Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
author_facet	Yang, Chang Liu, Jian-Feng Chai, Bai-Sheng Fang, Qin Chai, Ning Zhao, Li-Yan Xue, Yan-Xue Luo, Yi-Xiao Jian, Min Han, Ying Shi, Hai-Shui Lu, Lin Wu, Ping Wang, Ji-Shi
author_sort	Yang, Chang
title	Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
title_short	Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
title_full	Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
title_fullStr	Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
title_full_unstemmed	Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
title_sort	stress within a restricted time window selectively affects the persistence of long-term memory
description	The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM) formation (tested 24 h later), but the effects of stress on the persistence of LTM (tested at least 1 week later) are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress) during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h) after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h) after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609809/
_version_	1611965761050378240

Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory

Similar Items