Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy and prevents cardiomyopathy in diabetic mice, albeit by an unknown mechanism. We hypothesized that AMPK-induced autophagy ameliorates diabetic...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Diabetes Association
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609561/ |