Central Synapses Release a Resource-Efficient Amount of Glutamate

Why synapses release a certain amount of neurotransmitter is poorly understood. Here we combine patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We find that, regardless of some uncertainty over synaptic...

Full description

Bibliographic Details
Main Authors: Savtchenko, Leonid P., Sylantyev, Sergiy, Rusakov, Dmitri A.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605778/