The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults
Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is signi...
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| Format: | Online |
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Medknow Publications & Media Pvt Ltd
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602988/ |
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pubmed-36029882013-04-05 The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults Shinozaki, Keiko Okuda, Masayuki Review Article Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is significant in people of European descent as well as Asians, but less significant among people of African descent. Although the variants were also associated with type 2 diabetes and glucose homeostasis, the associations were attenuated or abolished after adjusting for adiposity. The present review considers our current understanding of the effects of the FTO variants in different ethnic groups and in adults and children. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3602988/ /pubmed/23565494 http://dx.doi.org/10.4103/2230-8210.105576 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shinozaki, Keiko Okuda, Masayuki |
| spellingShingle |
Shinozaki, Keiko Okuda, Masayuki The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| author_facet |
Shinozaki, Keiko Okuda, Masayuki |
| author_sort |
Shinozaki, Keiko |
| title |
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| title_short |
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| title_full |
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| title_fullStr |
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| title_full_unstemmed |
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| title_sort |
effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults |
| description |
Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is significant in people of European descent as well as Asians, but less significant among people of African descent. Although the variants were also associated with type 2 diabetes and glucose homeostasis, the associations were attenuated or abolished after adjusting for adiposity. The present review considers our current understanding of the effects of the FTO variants in different ethnic groups and in adults and children. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602988/ |
| _version_ |
1611963950833860608 |