Leptin, diabetes, and the brain

Diabetes is a major worldwide problem. Despite some progress in the development of new antidiabetic agents, the ability to maintain tight glycemic control in order to prevent renal, retinal, and neuropathic complications of diabetes without adverse complications still remains a challenge. Recent evi...

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Main Authors:	Meek, Thomas H., Morton, Gregory J.
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602981/

id	pubmed-3602981
recordtype	oai_dc
spelling	pubmed-36029812013-04-05 Leptin, diabetes, and the brain Meek, Thomas H. Morton, Gregory J. Review Article Diabetes is a major worldwide problem. Despite some progress in the development of new antidiabetic agents, the ability to maintain tight glycemic control in order to prevent renal, retinal, and neuropathic complications of diabetes without adverse complications still remains a challenge. Recent evidence suggests, however, that in addition to playing a key role in the regulation of energy homeostasis, the adiposity hormone leptin also plays an important role in the control of glucose metabolism via its actions in the brain. This review examines the role of leptin action in the central nervous system and the mechanisms whereby leptin mediates its effects to regulate glucose metabolism. These findings suggest that defects or dysfunction in leptin signaling may contribute to the etiology of diabetes and raise the possibility that either leptin or downstream targets of leptin may have therapeutic potential for the treatment of diabetes. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3602981/ /pubmed/23565487 http://dx.doi.org/10.4103/2230-8210.105568 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Meek, Thomas H. Morton, Gregory J.
spellingShingle	Meek, Thomas H. Morton, Gregory J. Leptin, diabetes, and the brain
author_facet	Meek, Thomas H. Morton, Gregory J.
author_sort	Meek, Thomas H.
title	Leptin, diabetes, and the brain
title_short	Leptin, diabetes, and the brain
title_full	Leptin, diabetes, and the brain
title_fullStr	Leptin, diabetes, and the brain
title_full_unstemmed	Leptin, diabetes, and the brain
title_sort	leptin, diabetes, and the brain
description	Diabetes is a major worldwide problem. Despite some progress in the development of new antidiabetic agents, the ability to maintain tight glycemic control in order to prevent renal, retinal, and neuropathic complications of diabetes without adverse complications still remains a challenge. Recent evidence suggests, however, that in addition to playing a key role in the regulation of energy homeostasis, the adiposity hormone leptin also plays an important role in the control of glucose metabolism via its actions in the brain. This review examines the role of leptin action in the central nervous system and the mechanisms whereby leptin mediates its effects to regulate glucose metabolism. These findings suggest that defects or dysfunction in leptin signaling may contribute to the etiology of diabetes and raise the possibility that either leptin or downstream targets of leptin may have therapeutic potential for the treatment of diabetes.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602981/
_version_	1611963947146018816

Leptin, diabetes, and the brain

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