Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma

Objective. The intrahepatic stem cells, also known as hepatic progenitor cells (HPCs), are able to differentiate into hepatocytes and bile duct epithelia. By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem c...

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Main Authors:	Jia, Shu-Qin, Ren, Jian-Jun, Dong, Pei-De, Meng, Xing-Kai
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600331/

id	pubmed-3600331
recordtype	oai_dc
spelling	pubmed-36003312013-03-26 Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma Jia, Shu-Qin Ren, Jian-Jun Dong, Pei-De Meng, Xing-Kai Research Article Objective. The intrahepatic stem cells, also known as hepatic progenitor cells (HPCs), are able to differentiate into hepatocytes and bile duct epithelia. By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem cells are involved in the pathogenesis of hepatocellular carcinoma. Methods. Immunohistochemistry was performed on 107 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte and hepatocellular carcinoma (HepPar1), biliary differentiation (CK7,CK19), haemopoietic stem cell (HSC) (c-kit/CD117, CD34, and Thy-1/CD90), HPC specific markers (OV-6), and Ki-67, p53 protein. Results. HPCs can be identified in the tumor nodules, around the edge of tumor nodules, and in the portal tracts of the paracirrhosis nodules being positive in HepPar1, CK7, CK19, and OV-6, but they failed to immunostain with CD117, CD34, and CD90. The HPCs positive in Ki-67 are observed in the tumor and paracirrhosis tissues. In 107 specimens, 40.2% (43/107) HCC tissues expressed p53 protein, lower than that of the HPCs around the tumor nodules (46.7%, 50/107) and much higher than that of the HPCs around the paracirrhosis nodules (8.41%, 9/107). Conclusion. Human hepatocellular carcinogenesis may be based on transformation of HPCs, not HSCs, through the formation of the transitional cells (hepatocyte-like cells and bile ductal cells). Hindawi Publishing Corporation 2013 2013-02-26 /pmc/articles/PMC3600331/ /pubmed/23533383 http://dx.doi.org/10.1155/2013/145253 Text en Copyright © 2013 Shu-Qin Jia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jia, Shu-Qin Ren, Jian-Jun Dong, Pei-De Meng, Xing-Kai
spellingShingle	Jia, Shu-Qin Ren, Jian-Jun Dong, Pei-De Meng, Xing-Kai Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
author_facet	Jia, Shu-Qin Ren, Jian-Jun Dong, Pei-De Meng, Xing-Kai
author_sort	Jia, Shu-Qin
title	Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
title_short	Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
title_full	Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
title_fullStr	Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
title_full_unstemmed	Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma
title_sort	probing the hepatic progenitor cell in human hepatocellular carcinoma
description	Objective. The intrahepatic stem cells, also known as hepatic progenitor cells (HPCs), are able to differentiate into hepatocytes and bile duct epithelia. By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem cells are involved in the pathogenesis of hepatocellular carcinoma. Methods. Immunohistochemistry was performed on 107 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte and hepatocellular carcinoma (HepPar1), biliary differentiation (CK7,CK19), haemopoietic stem cell (HSC) (c-kit/CD117, CD34, and Thy-1/CD90), HPC specific markers (OV-6), and Ki-67, p53 protein. Results. HPCs can be identified in the tumor nodules, around the edge of tumor nodules, and in the portal tracts of the paracirrhosis nodules being positive in HepPar1, CK7, CK19, and OV-6, but they failed to immunostain with CD117, CD34, and CD90. The HPCs positive in Ki-67 are observed in the tumor and paracirrhosis tissues. In 107 specimens, 40.2% (43/107) HCC tissues expressed p53 protein, lower than that of the HPCs around the tumor nodules (46.7%, 50/107) and much higher than that of the HPCs around the paracirrhosis nodules (8.41%, 9/107). Conclusion. Human hepatocellular carcinogenesis may be based on transformation of HPCs, not HSCs, through the formation of the transitional cells (hepatocyte-like cells and bile ductal cells).
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600331/
_version_	1611963300251172864

Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma

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