The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions

The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions

Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). Thus, pharmacological interventions which stabilize MC...

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Bibliographic Details
Main Authors: Yousefi, Omid Sascha, Wilhelm, Thomas, Maschke-Neuß, Karin, Kuhny, Marcel, Martin, Christian, Molderings, Gerhard J, Kratz, Felix, Hildenbrand, Bernd, Huber, Michael
Format: Online
Language:English
Published: BioMed Central 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598916/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598916/

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