Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome
Mutations in the WAS gene cause Wiskott-Aldrich syndrome (WAS), which is characterized by eczema, immunodeficiency and microthrombocytopenia. Although the role of WASP in lymphocytes and myeloid cells is well characterized, its role on megakaryocyte (MK) development is poorly understood. In order to...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists Limited
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597037/ |