Mutational screening of affected cardiac tissues and peripheral blood cells identified novel somatic mutations in GATA4 in patients with ventricular septal defect☆

Mutational screening of affected cardiac tissues and peripheral blood cells identified novel somatic mutations in GATA4 in patients with ventricular septal defect☆

The aim of this study was to examine how somatic mutations of the GATA4 gene contributed to the genesis of ventricular septal defect (VSD). The coding and intron-exon boundary regions of GATA4 were sequenced of DNA samples from peripheral blood cells and cardiac tissues of twenty surgically treated...

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Bibliographic Details
Main Authors: Cheng, Chunyan, Lin, Yuan, Yang, Fan, Wang, Wenjing, Wu, Chong, Qin, Jingli, Shao, Xiuqin, Zhou, Lei
Format: Online
Language:English
Published: Editorial Department of Journal of Biomedical Research 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596722/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596722/

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