Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells☆
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Current therapy includes surgery, radiation and chemotherapy with temozolomide (TMZ). Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) pro...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Editorial Department of Journal of Biomedical Research
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596690/ |