Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challe...

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Bibliographic Details
Main Authors: Vélez, J I, Chandrasekharappa, S C, Henao, E, Martinez, A F, Harper, U, Jones, M, Solomon, B D, Lopez, L, Garcia, G, Aguirre-Acevedo, D C, Acosta-Baena, N, Correa, J C, Lopera-Gómez, C M, Jaramillo-Elorza, M C, Rivera, D, Kosik, K S, Schork, N J, Swanson, J M, Lopera, F, Arcos-Burgos, M
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596442/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596442/

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