Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance

Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance

Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca2+-handling in pancreatic β cells. Insulin secretion is triggered by elevation in cytoplasmic Ca2+ concentration ([Ca2+]cyt) of β cells. This elevation in [Ca2+]cy...

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Bibliographic Details
Main Authors: Dixit, Sayali S., Wang, Tiannan, Manzano, Eiffel John Q., Yoo, Shin, Lee, Jeongkyung, Chiang, David Y., Ryan, Nicole, Respress, Jonathan L., Yechoor, Vijay K., Wehrens, Xander H. T.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596297/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596297/

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