COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux
The study of patient tissues and cell lines shows that SCO1 and SCO2 function collaboratively to generate a redox-dependent signal that is transduced from mitochondria to the cytosol by COX19, where it is relayed to ATP7A to regulate the rate of copper efflux from the cell.
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596241/ |