Roles of IL-22 in Allergic Airway Inflammation

Roles of IL-22 in Allergic Airway Inflammation

IL-23- and IL-17A-producing CD4+ T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, a...

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Main Authors: Hirose, Koichi, Takahashi, Kentaro, Nakajima, Hiroshi
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594983/
id pubmed-3594983
recordtype oai_dc
spelling pubmed-35949832013-04-10 Roles of IL-22 in Allergic Airway Inflammation Hirose, Koichi Takahashi, Kentaro Nakajima, Hiroshi Review Article IL-23- and IL-17A-producing CD4+ T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the site of allergic airway inflammation and to inhibit allergic inflammation in mice. In addition to Th17 cells, innate lymphoid cells also produce IL-22 in response to allergen challenge. Functional IL-22 receptor complex is expressed on lung epithelial cells, and IL-22 inhibits cytokine and chemokine production from lung epithelial cells. In this paper, we summarize the recent progress on the roles of IL-22 in the regulation of allergic airway inflammation and discuss its therapeutic potential in asthma. Hindawi Publishing Corporation 2013 2013-02-21 /pmc/articles/PMC3594983/ /pubmed/23577040 http://dx.doi.org/10.1155/2013/260518 Text en Copyright © 2013 Koichi Hirose et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Hirose, Koichi
Takahashi, Kentaro
Nakajima, Hiroshi
spellingShingle Hirose, Koichi
Takahashi, Kentaro
Nakajima, Hiroshi
Roles of IL-22 in Allergic Airway Inflammation
author_facet Hirose, Koichi
Takahashi, Kentaro
Nakajima, Hiroshi
author_sort Hirose, Koichi
title Roles of IL-22 in Allergic Airway Inflammation
title_short Roles of IL-22 in Allergic Airway Inflammation
title_full Roles of IL-22 in Allergic Airway Inflammation
title_fullStr Roles of IL-22 in Allergic Airway Inflammation
title_full_unstemmed Roles of IL-22 in Allergic Airway Inflammation
title_sort roles of il-22 in allergic airway inflammation
description IL-23- and IL-17A-producing CD4+ T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the site of allergic airway inflammation and to inhibit allergic inflammation in mice. In addition to Th17 cells, innate lymphoid cells also produce IL-22 in response to allergen challenge. Functional IL-22 receptor complex is expressed on lung epithelial cells, and IL-22 inhibits cytokine and chemokine production from lung epithelial cells. In this paper, we summarize the recent progress on the roles of IL-22 in the regulation of allergic airway inflammation and discuss its therapeutic potential in asthma.
publisher Hindawi Publishing Corporation
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594983/
_version_ 1611961444748754944

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