Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis

A 73-year-old female, who suffered from rheumatoid arthritis for 10 years, developed precore mutant hepatitis B virus-associated fulminant hepatitis after 1 year of infliximab therapy and subsequent methotrexate withdrawal. We emphasize the importance of preemptive antiviral therapy before starting...

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Bibliographic Details
Main Authors: Kuwabara, Hiroko, Fukuda, Akira, Tsuda, Yasuhiro, Shibayama, Yuro
Format: Online
Language:English
Published: Springer-Verlag 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594820/
Description
Summary:A 73-year-old female, who suffered from rheumatoid arthritis for 10 years, developed precore mutant hepatitis B virus-associated fulminant hepatitis after 1 year of infliximab therapy and subsequent methotrexate withdrawal. We emphasize the importance of preemptive antiviral therapy before starting infliximab administration and withdrawing immunosuppressive drugs.