A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk

The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide s...

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Main Authors:	Berry, Sarah, Coppieters, Wouter, Davis, Stephen, Burrett, Alayna, Thomas, Natalie, Palmer, David, Kelly, Van, Obolonkin, Vladimir, Sanders, Kathryn, Spelman, Richard, Georges, Michel, Lehnert, Klaus, Snell, Russell
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594236/

id	pubmed-3594236
recordtype	oai_dc
spelling	pubmed-35942362013-03-27 A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk Berry, Sarah Coppieters, Wouter Davis, Stephen Burrett, Alayna Thomas, Natalie Palmer, David Kelly, Van Obolonkin, Vladimir Sanders, Kathryn Spelman, Richard Georges, Michel Lehnert, Klaus Snell, Russell Research Article The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA. Public Library of Science 2013-03-11 /pmc/articles/PMC3594236/ /pubmed/23536764 http://dx.doi.org/10.1371/journal.pone.0057219 Text en © 2013 Berry et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Berry, Sarah Coppieters, Wouter Davis, Stephen Burrett, Alayna Thomas, Natalie Palmer, David Kelly, Van Obolonkin, Vladimir Sanders, Kathryn Spelman, Richard Georges, Michel Lehnert, Klaus Snell, Russell
spellingShingle	Berry, Sarah Coppieters, Wouter Davis, Stephen Burrett, Alayna Thomas, Natalie Palmer, David Kelly, Van Obolonkin, Vladimir Sanders, Kathryn Spelman, Richard Georges, Michel Lehnert, Klaus Snell, Russell A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
author_facet	Berry, Sarah Coppieters, Wouter Davis, Stephen Burrett, Alayna Thomas, Natalie Palmer, David Kelly, Van Obolonkin, Vladimir Sanders, Kathryn Spelman, Richard Georges, Michel Lehnert, Klaus Snell, Russell
author_sort	Berry, Sarah
title	A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_short	A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_full	A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_fullStr	A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_full_unstemmed	A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_sort	triad of highly divergent polymeric immunoglobulin receptor (pigr) haplotypes with major effect on iga concentration in bovine milk
description	The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594236/
_version_	1611961299193823232

A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk

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