PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent insulinotropic G-protein-coupled receptor ligand, for which morphoregulative roles in pancreatic islets have recently been suggested. Here, we evaluated the effects of pancreatic overexpression of PACAP on morphometric changes of...

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Bibliographic Details
Main Authors: Inoue, Hiroaki, Shintani, Norihito, Sakurai, Yusuke, Higashi, Shintaro, Hayata-Takano, Atsuko, Baba, Akemichi, Hashimoto, Hitoshi
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593608/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593608/

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