Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

Recent studies in population of European ancestry have shown that 30%∼50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosom...

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Main Authors:	Yang, Jian, Lee, Taeheon, Kim, Jaemin, Cho, Myeong-Chan, Han, Bok-Ghee, Lee, Jong-Young, Lee, Hyun-Jeong, Cho, Seoae, Kim, Heebal
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591292/

id	pubmed-3591292
recordtype	oai_dc
spelling	pubmed-35912922013-03-15 Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans Yang, Jian Lee, Taeheon Kim, Jaemin Cho, Myeong-Chan Han, Bok-Ghee Lee, Jong-Young Lee, Hyun-Jeong Cho, Seoae Kim, Heebal Research Article Recent studies in population of European ancestry have shown that 30%∼50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosomes are in proportion to their length. Using genome-wide estimation and partitioning approaches, we analysed 49 human quantitative traits, many of which are relevant to human diseases, in 7,170 unrelated Korean individuals genotyped on 326,262 SNPs. For 43 of the 49 traits, we estimated a nominally significant (P<0.05) proportion of variance explained by all SNPs on the Affymetrix 5.0 genotyping array (). On average across 47 of the 49 traits for which the estimate of is non-zero, common SNPs explain approximately one-third (range of 7.8% to 76.8%) of narrow sense heritability. Public Library of Science 2013-03-07 /pmc/articles/PMC3591292/ /pubmed/23505390 http://dx.doi.org/10.1371/journal.pgen.1003355 Text en © 2013 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Jian Lee, Taeheon Kim, Jaemin Cho, Myeong-Chan Han, Bok-Ghee Lee, Jong-Young Lee, Hyun-Jeong Cho, Seoae Kim, Heebal
spellingShingle	Yang, Jian Lee, Taeheon Kim, Jaemin Cho, Myeong-Chan Han, Bok-Ghee Lee, Jong-Young Lee, Hyun-Jeong Cho, Seoae Kim, Heebal Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
author_facet	Yang, Jian Lee, Taeheon Kim, Jaemin Cho, Myeong-Chan Han, Bok-Ghee Lee, Jong-Young Lee, Hyun-Jeong Cho, Seoae Kim, Heebal
author_sort	Yang, Jian
title	Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
title_short	Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
title_full	Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
title_fullStr	Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
title_full_unstemmed	Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
title_sort	ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in koreans
description	Recent studies in population of European ancestry have shown that 30%∼50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosomes are in proportion to their length. Using genome-wide estimation and partitioning approaches, we analysed 49 human quantitative traits, many of which are relevant to human diseases, in 7,170 unrelated Korean individuals genotyped on 326,262 SNPs. For 43 of the 49 traits, we estimated a nominally significant (P<0.05) proportion of variance explained by all SNPs on the Affymetrix 5.0 genotyping array (). On average across 47 of the 49 traits for which the estimate of is non-zero, common SNPs explain approximately one-third (range of 7.8% to 76.8%) of narrow sense heritability.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591292/
_version_	1611960623615180800

Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

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