Bodyweight Assessment of Enamelin Null Mice

The Enam null mice appear to be smaller than wild-type mice, which prompted the hypothesis that enamel defects negatively influence nutritional intake and bodyweight gain (BWG). We compared the BWG of Enam−/− and wild-type mice from birth (D0) to Day 42 (D42). Wild-type (WT) and Enam−/− (N) mice wer...

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Main Authors:	Chan, Albert H.-L., Lertlam, Rangsiyakorn, Simmer, James P., Wang, Chia-Ning, Hu, Jan C. C.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591218/

id	pubmed-3591218
recordtype	oai_dc
spelling	pubmed-35912182013-03-18 Bodyweight Assessment of Enamelin Null Mice Chan, Albert H.-L. Lertlam, Rangsiyakorn Simmer, James P. Wang, Chia-Ning Hu, Jan C. C. Research Article The Enam null mice appear to be smaller than wild-type mice, which prompted the hypothesis that enamel defects negatively influence nutritional intake and bodyweight gain (BWG). We compared the BWG of Enam−/− and wild-type mice from birth (D0) to Day 42 (D42). Wild-type (WT) and Enam−/− (N) mice were given either hard chow (HC) or soft chow (SC). Four experimental groups were studied: WTHC, WTSC, NHC, and NSC. The mother's bodyweight (DBW) and the average litter bodyweight (ALBW) were obtained from D0 to D21. After D21, the pups were separated from the mother and provided the same type of food. Litter bodyweights were measured until D42. ALBW was compared at 7-day intervals using one-way ANOVA, while the influence of DBW on ALBW was analyzed by mixed-model analyses. The ALBW of Enam−/− mice maintained on hard chow (NHC) was significantly lower than the two WT groups at D21 and the differences persisted into young adulthood. The ALBW of Enam−/− mice maintained on soft chow (NSC) trended lower, but was not significantly different than that of the WT groups. We conclude that genotype, which affects enamel integrity, and food hardness influence bodyweight gain in postnatal and young adult mice. Hindawi Publishing Corporation 2013 2012-12-26 /pmc/articles/PMC3591218/ /pubmed/23509695 http://dx.doi.org/10.1155/2013/246861 Text en Copyright © 2013 Albert H.-L. Chan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chan, Albert H.-L. Lertlam, Rangsiyakorn Simmer, James P. Wang, Chia-Ning Hu, Jan C. C.
spellingShingle	Chan, Albert H.-L. Lertlam, Rangsiyakorn Simmer, James P. Wang, Chia-Ning Hu, Jan C. C. Bodyweight Assessment of Enamelin Null Mice
author_facet	Chan, Albert H.-L. Lertlam, Rangsiyakorn Simmer, James P. Wang, Chia-Ning Hu, Jan C. C.
author_sort	Chan, Albert H.-L.
title	Bodyweight Assessment of Enamelin Null Mice
title_short	Bodyweight Assessment of Enamelin Null Mice
title_full	Bodyweight Assessment of Enamelin Null Mice
title_fullStr	Bodyweight Assessment of Enamelin Null Mice
title_full_unstemmed	Bodyweight Assessment of Enamelin Null Mice
title_sort	bodyweight assessment of enamelin null mice
description	The Enam null mice appear to be smaller than wild-type mice, which prompted the hypothesis that enamel defects negatively influence nutritional intake and bodyweight gain (BWG). We compared the BWG of Enam−/− and wild-type mice from birth (D0) to Day 42 (D42). Wild-type (WT) and Enam−/− (N) mice were given either hard chow (HC) or soft chow (SC). Four experimental groups were studied: WTHC, WTSC, NHC, and NSC. The mother's bodyweight (DBW) and the average litter bodyweight (ALBW) were obtained from D0 to D21. After D21, the pups were separated from the mother and provided the same type of food. Litter bodyweights were measured until D42. ALBW was compared at 7-day intervals using one-way ANOVA, while the influence of DBW on ALBW was analyzed by mixed-model analyses. The ALBW of Enam−/− mice maintained on hard chow (NHC) was significantly lower than the two WT groups at D21 and the differences persisted into young adulthood. The ALBW of Enam−/− mice maintained on soft chow (NSC) trended lower, but was not significantly different than that of the WT groups. We conclude that genotype, which affects enamel integrity, and food hardness influence bodyweight gain in postnatal and young adult mice.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591218/
_version_	1611960583654998016

Bodyweight Assessment of Enamelin Null Mice

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