Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease

Animal studies suggest that renal tissue hypoxia plays an important role in the development of renal damage in hypertension and renal diseases, yet human data were scarce due to the lack of noninvasive methods. Over the last decade, blood oxygenation level-dependent magnetic resonance imaging (BOLD-...

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Main Authors:	Pruijm, Menno, Hofmann, Lucie, Vogt, Bruno, Muller, Marie-Eve, Piskunowicz, Maciej, Stuber, Matthias, Burnier, Michel
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590788/

id	pubmed-3590788
recordtype	oai_dc
spelling	pubmed-35907882013-03-18 Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease Pruijm, Menno Hofmann, Lucie Vogt, Bruno Muller, Marie-Eve Piskunowicz, Maciej Stuber, Matthias Burnier, Michel Review Article Animal studies suggest that renal tissue hypoxia plays an important role in the development of renal damage in hypertension and renal diseases, yet human data were scarce due to the lack of noninvasive methods. Over the last decade, blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI), detecting deoxyhemoglobin in hypoxic renal tissue, has become a powerful tool to assess kidney oxygenation noninvasively in humans. This paper provides an overview of BOLD-MRI studies performed in patients suffering from essential hypertension or chronic kidney disease (CKD). In line with animal studies, acute changes in cortical and medullary oxygenation have been observed after the administration of medication (furosemide, blockers of the renin-angiotensin system) or alterations in sodium intake in these patient groups, underlining the important role of renal sodium handling in kidney oxygenation. In contrast, no BOLD-MRI studies have convincingly demonstrated that renal oxygenation is chronically reduced in essential hypertension or in CKD or chronically altered after long-term medication intake. More studies are required to clarify this discrepancy and to further unravel the role of renal oxygenation in the development and progression of essential hypertension and CKD in humans. Hindawi Publishing Corporation 2013 2013-02-20 /pmc/articles/PMC3590788/ /pubmed/23509612 http://dx.doi.org/10.1155/2013/696598 Text en Copyright © 2013 Menno Pruijm et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pruijm, Menno Hofmann, Lucie Vogt, Bruno Muller, Marie-Eve Piskunowicz, Maciej Stuber, Matthias Burnier, Michel
spellingShingle	Pruijm, Menno Hofmann, Lucie Vogt, Bruno Muller, Marie-Eve Piskunowicz, Maciej Stuber, Matthias Burnier, Michel Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
author_facet	Pruijm, Menno Hofmann, Lucie Vogt, Bruno Muller, Marie-Eve Piskunowicz, Maciej Stuber, Matthias Burnier, Michel
author_sort	Pruijm, Menno
title	Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
title_short	Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
title_full	Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
title_fullStr	Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
title_full_unstemmed	Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease
title_sort	renal tissue oxygenation in essential hypertension and chronic kidney disease
description	Animal studies suggest that renal tissue hypoxia plays an important role in the development of renal damage in hypertension and renal diseases, yet human data were scarce due to the lack of noninvasive methods. Over the last decade, blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI), detecting deoxyhemoglobin in hypoxic renal tissue, has become a powerful tool to assess kidney oxygenation noninvasively in humans. This paper provides an overview of BOLD-MRI studies performed in patients suffering from essential hypertension or chronic kidney disease (CKD). In line with animal studies, acute changes in cortical and medullary oxygenation have been observed after the administration of medication (furosemide, blockers of the renin-angiotensin system) or alterations in sodium intake in these patient groups, underlining the important role of renal sodium handling in kidney oxygenation. In contrast, no BOLD-MRI studies have convincingly demonstrated that renal oxygenation is chronically reduced in essential hypertension or in CKD or chronically altered after long-term medication intake. More studies are required to clarify this discrepancy and to further unravel the role of renal oxygenation in the development and progression of essential hypertension and CKD in humans.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590788/
_version_	1611960408936022016

Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease

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