The Impact of 3′UTR Variants on Differential Expression of Candidate Cancer Susceptibility Genes
Variants in regulatory regions are predicted to play an important role in disease susceptibility of common diseases. Polymorphisms mapping to microRNA (miRNA) binding sites have been shown to disrupt the ability of miRNAs to target genes resulting in differential mRNA and protein expression. Skin tu...
Main Authors: | Skeeles, Laura E., Fleming, Jessica L., Mahler, Kimberly L., Toland, Amanda Ewart |
---|---|
Format: | Online |
Language: | English |
Published: |
Public Library of Science
2013
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589377/ |
Similar Items
-
Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice
by: Fleming, Jessica L., et al.
Published: (2013) -
Complexity of the 5′UTR region of the CLCN5 gene: eleven 5′UTR ends are differentially expressed in the human kidney
by: Tosetto, Enrica, et al.
Published: (2014) -
Genetic variants in 3′-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans
by: Joo Jeon, Young, et al.
Published: (2015) -
Functional polymorphism in the 5′-UTR of CR2 is associated with susceptibility to nasopharyngeal carcinoma
by: FAN, QIN, et al.
Published: (2013) -
Association of genetic variants in the 3′UTR of HLA-G with Recurrent Pregnancy Loss
by: Amodio, Giada, et al.
Published: (2016)