Expression of NDRG2 in human lung cancer and its correlation with prognosis

We had reported that N-myc downstream–regulated gene (NDRG2) regulates colorectal cancer, breast cancer, clear cell renal cell carcinoma, pancreatic cancer, thyroid cancer and esophageal squamous cell proliferation, development, and apoptosis. The goal of this study was to determine the expression p...

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Main Authors:	Li, Shu-jun, Wang, Wen-yong, Li, Bing, Chen, Bei, Zhang, Bo, Wang, Xin, Chen, Chang-sheng, Zhao, Qing-chuan, Shi, Hai, Yao, Libo
Format:	Online
Language:	English
Published:	Springer US 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586402/

id	pubmed-3586402
recordtype	oai_dc
spelling	pubmed-35864022013-03-07 Expression of NDRG2 in human lung cancer and its correlation with prognosis Li, Shu-jun Wang, Wen-yong Li, Bing Chen, Bei Zhang, Bo Wang, Xin Chen, Chang-sheng Zhao, Qing-chuan Shi, Hai Yao, Libo Original Paper We had reported that N-myc downstream–regulated gene (NDRG2) regulates colorectal cancer, breast cancer, clear cell renal cell carcinoma, pancreatic cancer, thyroid cancer and esophageal squamous cell proliferation, development, and apoptosis. The goal of this study was to determine the expression pattern of NDRG2 in human lung cancer and its correlation with prognosis. Immunohistochemistry, RT-PCR and western blot were used to explore the expression of NDRG2 in 185 human lung cancer patients. The correlation of NDRG2 expression with patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Results showed that the expression level of NDRG2 was decreased in human lung cancer tissues, and NDRG2 was positively correlated with depth of invasion (P = 0.038), vascular invasion (P = 0.036), tumor grade (P = 0.039), and tumor size (P = 0.026). Both RT-PCR and Western blots demonstrated that NDRG2 mRNA and protein levels were lower in lung cancer compared to the adjacent normal tissue from the same individual, and NDRG2 level was negatively correlated with UICC stage. Additionally, survival time of lung cancer patients with high expression of NDRG2 was longer than those with low expression during the 5-year follow-up period (P = 0.001). Meanwhile, COX regression analysis indicated that low expression of NDRG2, ≥pT3, pM1, ≥pN1 and vascular invasion were independent, poor prognostic factors of lung cancer patients. These data showed that NDRG2 may play an important role in human lung cancer tumourigenesis, and NDRG2 might serve as a novel prognostic marker in human lung cancer. Springer US 2013-01-10 2013-03 /pmc/articles/PMC3586402/ /pubmed/23307246 http://dx.doi.org/10.1007/s12032-012-0421-7 Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Li, Shu-jun Wang, Wen-yong Li, Bing Chen, Bei Zhang, Bo Wang, Xin Chen, Chang-sheng Zhao, Qing-chuan Shi, Hai Yao, Libo
spellingShingle	Li, Shu-jun Wang, Wen-yong Li, Bing Chen, Bei Zhang, Bo Wang, Xin Chen, Chang-sheng Zhao, Qing-chuan Shi, Hai Yao, Libo Expression of NDRG2 in human lung cancer and its correlation with prognosis
author_facet	Li, Shu-jun Wang, Wen-yong Li, Bing Chen, Bei Zhang, Bo Wang, Xin Chen, Chang-sheng Zhao, Qing-chuan Shi, Hai Yao, Libo
author_sort	Li, Shu-jun
title	Expression of NDRG2 in human lung cancer and its correlation with prognosis
title_short	Expression of NDRG2 in human lung cancer and its correlation with prognosis
title_full	Expression of NDRG2 in human lung cancer and its correlation with prognosis
title_fullStr	Expression of NDRG2 in human lung cancer and its correlation with prognosis
title_full_unstemmed	Expression of NDRG2 in human lung cancer and its correlation with prognosis
title_sort	expression of ndrg2 in human lung cancer and its correlation with prognosis
description	We had reported that N-myc downstream–regulated gene (NDRG2) regulates colorectal cancer, breast cancer, clear cell renal cell carcinoma, pancreatic cancer, thyroid cancer and esophageal squamous cell proliferation, development, and apoptosis. The goal of this study was to determine the expression pattern of NDRG2 in human lung cancer and its correlation with prognosis. Immunohistochemistry, RT-PCR and western blot were used to explore the expression of NDRG2 in 185 human lung cancer patients. The correlation of NDRG2 expression with patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Results showed that the expression level of NDRG2 was decreased in human lung cancer tissues, and NDRG2 was positively correlated with depth of invasion (P = 0.038), vascular invasion (P = 0.036), tumor grade (P = 0.039), and tumor size (P = 0.026). Both RT-PCR and Western blots demonstrated that NDRG2 mRNA and protein levels were lower in lung cancer compared to the adjacent normal tissue from the same individual, and NDRG2 level was negatively correlated with UICC stage. Additionally, survival time of lung cancer patients with high expression of NDRG2 was longer than those with low expression during the 5-year follow-up period (P = 0.001). Meanwhile, COX regression analysis indicated that low expression of NDRG2, ≥pT3, pM1, ≥pN1 and vascular invasion were independent, poor prognostic factors of lung cancer patients. These data showed that NDRG2 may play an important role in human lung cancer tumourigenesis, and NDRG2 might serve as a novel prognostic marker in human lung cancer.
publisher	Springer US
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586402/
_version_	1611958920788574208

Expression of NDRG2 in human lung cancer and its correlation with prognosis

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