Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation
► We hypothesize that neurodegeneration in anti-NGF is due to NGF/proNGF imbalance. ► We propose that the proNGF co- receptor sortilin contributes to the neurodegeneration. ► We analyzed anti-NGF mice crossed to sortilin knockout mice. ► Sortilin loss partially protected AD10 anti-NGF mice from neur...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Academic Press
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585961/ |