Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral v...

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Bibliographic Details
Main Authors: Kiezun, Adam, Pulit, Sara L., Francioli, Laurent C., van Dijk, Freerk, Swertz, Morris, Boomsma, Dorret I., van Duijn, Cornelia M., Slagboom, P. Eline, van Ommen, G. J. B., Wijmenga, Cisca, de Bakker, Paul I. W., Sunyaev, Shamil R.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585140/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585140/

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