Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets

Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets

Transcription factor (TF)–induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been proposed as a defining mark that distinguishes the...

Full description

Bibliographic Details
Main Authors: Fragola, Giulia, Germain, Pierre-Luc, Laise, Pasquale, Cuomo, Alessandro, Blasimme, Alessandro, Gross, Fridolin, Signaroldi, Elena, Bucci, Gabriele, Sommer, Cesar, Pruneri, Giancarlo, Mazzarol, Giovanni, Bonaldi, Tiziana, Mostoslavsky, Gustavo, Casola, Stefano, Testa, Giuseppe
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585017/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585017/

Similar Items