Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells

Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells

We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype...

Full description

Bibliographic Details
Main Authors:	Park, Sung Nam, Tae Noh, Kyung, Jeong, Young-Il, Duk Jung, In, Kyu Kang, Hyun, Sun Cha, Gil, Jung Lee, Su, Keun Seo, Jong, Hwan Kang, Dae, Hwang, Tae-Ho, Kyung Lee, Eun, Kwon, Byungsuk, Park, Yeong-Min
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584663/

Similar Items

The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
by: Noh, Kyung Tae, et al.
Published: (2012)

The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4
by: Lee, Su Jung, et al.
Published: (2014)

Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response
by: Lee, Su Jung, et al.
Published: (2014)

Toll-like receptor 3-induced immune response by poly(d,l-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy
by: Han, Hee Dong, et al.
Published: (2016)

Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine
by: Lee, Jun Sik, et al.
Published: (2011)

Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3β-mediated B-cell lymphoma 2 regulation
by: Noh, Kyung Tae, et al.
Published: (2016)

Herbal preparation (HemoHIM) enhanced functional maturation of bone marrow-derived dendritic cells mediated toll-like receptor 4
by: Lee, Sung-Ju, et al.
Published: (2016)

Natural toll-like receptor agonists in prophylactic vaccines for dendritic cell activation
by: Peng, Paul, et al.
Published: (2015)

Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity
by: Vo, Manh-Cuong, et al.
Published: (2015)

Rhamnogalacturonan-I Based Microcapsules for Targeted Drug Release
by: Svagan, Anna J., et al.
Published: (2016)

Synthesis of borate cross-linked rhamnogalacturonan II
by: Funakawa, Hiroya, et al.
Published: (2015)

A Potential Protein Adjuvant Derived from Mycobacterium tuberculosis Rv0652 Enhances Dendritic Cells-Based Tumor Immunotherapy
by: Lee, Seung Jun, et al.
Published: (2014)

Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
by: Noh, Kyung Tae, et al.
Published: (2015)

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4
by: Kang, Tae Heung, et al.
Published: (2015)

Multi-scale spatial heterogeneity of pectic rhamnogalacturonan I (RG–I) structural features in tobacco seed endosperm cell walls
by: Lee, Kieran JD, et al.
Published: (2013)

Synergy between Vitamin D3 and Toll-Like Receptor Agonists Regulates Human Dendritic Cell Response during Maturation
by: Brosbøl-Ravnborg, Anne, et al.
Published: (2013)

Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100
by: Naumann, Kai, et al.
Published: (2013)

Modulation of Female Genital Tract-Derived Dendritic Cell Migration and Activation in Response to Inflammatory Cytokines and Toll-Like Receptor Agonists
by: Shey, Muki S., et al.
Published: (2016)

Effects of high glucose on interleukin-6 production in human mesangial cells.
by: Ihm, Chun-Gyoo, et al.
Published: (2002)

Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells
by: Kwak, Tae Won, et al.
Published: (2016)

The expression and function of toll-like receptors (TLRs) in ovarian cancer cell lines
by: Lee, Shin-Wha, et al.
Published: (2015)

Glycosylinositol phosphorylceramides from Rosa cell cultures are boron-bridged in the plasma membrane and form complexes with rhamnogalacturonan II
by: Voxeur, Aline, et al.
Published: (2014)

Nanoparticle-Based Vaccine Delivery for Cancer Immunotherapy
by: Park, Yeong-Min, et al.
Published: (2013)

Toll-Like Receptor Agonists Modulate Wound Regeneration in Airway Epithelial Cells
by: Anna Lewandowska-Polak, et al.
Published: (2018-08-01)

GM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicity
by: Noh, Kyung Hee, et al.
Published: (2014)

The pathophysiological role of dendritic cell subsets in psoriasis
by: Kim, Tae-Gyun, et al.
Published: (2014)

Initial and Late Results of Freedom Coronary Stent
by: Ahn, Young Keun, et al.
Published: (2000)

Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro
by: Park, Jung-Sun, et al.
Published: (2011)

Dendritic planarity of Purkinje cells is independent of Reelin signaling
by: Kim, Jinkyung, et al.
Published: (2014)

In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates
by: Jung, Kyeong Cheon, et al.
Published: (2011)

Correction: In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates
by: Jung, Kyeong Cheon, et al.
Published: (2016)

Epstein-Barr virus-associated peripheral T-Cell lymphoma involving spleen in a renal transplant patient.
by: Lee, Hye Kyung, et al.
Published: (2003)

Stem Cells in Niemann-Pick Disease
by: Kim, Sun-Jung, et al.
Published: (2008)

Postoperative Clinical Outcome and Risk Factors for Poor Outcome of Foraminal and Extraforaminal Lumbar Disc Herniation
by: Bae, Jung Sik, et al.
Published: (2016)

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
by: Guiducci, Cristiana, et al.
Published: (2006)

Immunotherapy Using Dendritic Cells against Multiple Myeloma: How to Improve?
by: Nguyen-Pham, Thanh-Nhan, et al.
Published: (2012)

Hesperetin Alleviates the Inhibitory Effects of High Glucose on the Osteoblastic Differentiation of Periodontal Ligament Stem Cells
by: Kim, So Yeon, et al.
Published: (2013)

Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
by: Woo, Seong Ji, et al.
Published: (2016)

HaCaT Keratinocytes and Primary Epidermal Keratinocytes Have Different Transcriptional Profiles of Cornified Envelope-Associated Genes to T Helper Cell Cytokines
by: Seo, Min-Duk, et al.
Published: (2012)

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression
by: Verma, Vivek, et al.
Published: (2016)