Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

The statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been proven to be effective in lowering cholesterol and as anti-lipid agents against cardiovascular disease. Recent reports demonstrate an anticancer effect induced by the statins through inhibition of cell proliferation....

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Bibliographic Details
Main Authors: SPAMPANATO, CARMINE, DE MARIA, SALVATORE, SARNATARO, MADDALENA, GIORDANO, ELISABETTA, ZANFARDINO, MARIO, BAIANO, SALVATORE, CARTENÌ, MARIDELA, MORELLI, FRANCO
Format: Online
Language:English
Published: D.A. Spandidos 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584570/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584570/

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