HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) have been reported to exert cytoprotective activity in the area of tissue injury. However, hypoxia/oxidative stress prevailing in the area of injury could activate p53, leading to death and differentiation of hESCs. Here we report that when exposed to hypoxia/oxida...

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Bibliographic Details
Main Authors: Das, Bikul, Bayat-Mokhtari, Reza, Tsui, Micky, Lotfi, Shamim, Tsuchida, Rika, Felsher, Dean W, Yeger, Herman
Format: Online
Language:English
Published: Wiley Subscription Services, Inc., A Wiley Company 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519/

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