Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in most cells. This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. Although complex IV is the best studied of these complexe...

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Main Authors: Quintens, Roel, Singh, Sarvjeet, Lemaire, Katleen, De Bock, Katrien, Granvik, Mikaela, Schraenen, Anica, Vroegrijk, Irene Olga Cornelia Maria, Costa, Veronica, Van Noten, Pieter, Lambrechts, Dennis, Lehnert, Stefan, Van Lommel, Leentje, Thorrez, Lieven, De Faudeur, Geoffroy, Romijn, Johannes Anthonius, Shelton, John Michael, Scorrano, Luca, Lijnen, Henri Roger, Voshol, Peter Jacobus, Carmeliet, Peter, Mammen, Pradeep Puthenveetil Abraham, Schuit, Frans
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584060/

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