Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells
The genome-protecting role of poly(ADP-ribose) (PAR) has identified PAR polymerase-1 (PARP-1) and PAR glycohydrolase (PARG), two enzymes responsible for the synthesis and hydrolysis of PAR, as chemotherapeutic targets. Each has been previously individually evaluated in chemotherapy, but the effects...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583631/ |