Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

The synthetic retinoid, Fenretinide (FEN), inhibits obesity and insulin resistance in mice and is in early clinical trials for treatment of insulin resistance in obese humans. We aimed to determine whether alterations in retinoic acid (RA)-responsive genes contribute to the beneficial effects of FEN...

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Bibliographic Details
Main Authors: Mcilroy, George D., Delibegovic, Mirela, Owen, Carl, Stoney, Patrick N., Shearer, Kirsty D., McCaffery, Peter J., Mody, Nimesh
Format: Online
Language:English
Published: American Diabetes Association 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581207/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581207/

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