Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model

Previous research from our group has demonstrated arsenic trioxide eluting stents significantly reduced neointimal area and thickness compared with bare metal stents. In the present study, the anti-inflammatory effects of arsenic trioxide in vitro and arsenic trioxide eluting stents in a porcine cor...

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Main Authors:	Shen, Li, Gong, Feirong, Tian, Wenjie, Li, Weiming, Zhang, Feng, Qian, Juying, Sun, Aijun, Zou, Yunzeng, Yang, Wei, Ge, Junbo
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581093/

id	pubmed-3581093
recordtype	oai_dc
spelling	pubmed-35810932013-03-18 Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model Shen, Li Gong, Feirong Tian, Wenjie Li, Weiming Zhang, Feng Qian, Juying Sun, Aijun Zou, Yunzeng Yang, Wei Ge, Junbo Research Article Previous research from our group has demonstrated arsenic trioxide eluting stents significantly reduced neointimal area and thickness compared with bare metal stents. In the present study, the anti-inflammatory effects of arsenic trioxide in vitro and arsenic trioxide eluting stents in a porcine coronary model have been explored. Sixty-five pigs underwent placement of 139 oversized stents in the coronary arteries with histologic analysis, endothelial function analysis, and immunohistochemical and western blot analyses. Arsenic trioxide eluting stents effectively inhibited local inflammatory reactions, while no significant difference in endothelialization and endothelial function between arsenic trioxide eluting stents and bare metal stents was observed. Arsenic trioxide eluting stents favorably modulate neointimal formation due to less augmentation of early inflammatory reactions, and quick endothelialization of the stent surface, which might contribute to long-term safety and efficacy of drug eluting stents. Hindawi Publishing Corporation 2013 2013-01-16 /pmc/articles/PMC3581093/ /pubmed/23509814 http://dx.doi.org/10.1155/2013/937936 Text en Copyright © 2013 Li Shen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Shen, Li Gong, Feirong Tian, Wenjie Li, Weiming Zhang, Feng Qian, Juying Sun, Aijun Zou, Yunzeng Yang, Wei Ge, Junbo
spellingShingle	Shen, Li Gong, Feirong Tian, Wenjie Li, Weiming Zhang, Feng Qian, Juying Sun, Aijun Zou, Yunzeng Yang, Wei Ge, Junbo Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
author_facet	Shen, Li Gong, Feirong Tian, Wenjie Li, Weiming Zhang, Feng Qian, Juying Sun, Aijun Zou, Yunzeng Yang, Wei Ge, Junbo
author_sort	Shen, Li
title	Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
title_short	Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
title_full	Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
title_fullStr	Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
title_full_unstemmed	Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model
title_sort	anti-inflammatory effects of arsenic trioxide eluting stents in a porcine coronary model
description	Previous research from our group has demonstrated arsenic trioxide eluting stents significantly reduced neointimal area and thickness compared with bare metal stents. In the present study, the anti-inflammatory effects of arsenic trioxide in vitro and arsenic trioxide eluting stents in a porcine coronary model have been explored. Sixty-five pigs underwent placement of 139 oversized stents in the coronary arteries with histologic analysis, endothelial function analysis, and immunohistochemical and western blot analyses. Arsenic trioxide eluting stents effectively inhibited local inflammatory reactions, while no significant difference in endothelialization and endothelial function between arsenic trioxide eluting stents and bare metal stents was observed. Arsenic trioxide eluting stents favorably modulate neointimal formation due to less augmentation of early inflammatory reactions, and quick endothelialization of the stent surface, which might contribute to long-term safety and efficacy of drug eluting stents.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581093/
_version_	1611957282632892416

Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model

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