Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer

The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin a...

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Main Authors:	ZHANG, GUO-AN, HOU, SEN, HAN, SHA, ZHOU, JIAN, WANG, XU, CUI, WEN
Format:	Online
Language:	English
Published:	D.A. Spandidos 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576217/

id	pubmed-3576217
recordtype	oai_dc
spelling	pubmed-35762172013-02-20 Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer ZHANG, GUO-AN HOU, SEN HAN, SHA ZHOU, JIAN WANG, XU CUI, WEN Articles The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin and OBRs in 76 PTC samples using immunohistochemistry, and their associations with clinicopathological parameters were evaluated. The expression of OBRs was observed in the tumor cell membrane and/or cytoplasm, with a positive rate of 73.7% (56/76), while leptin was expressed in the tumor cell cytoplasm in 55 of 76 cases (72.4%). The expression of either protein was associated with greater tumor size (P=0.016 for leptin and P=0.002 for OBRs). In addition, the expression levels of leptin and OBRs were associated with each other. Neither leptin nor OBR expression levels were associated with other parameters, including age, body weight, postmenopausal state, multifocality and lymph node metastasis. These data suggest that the expression of leptin and/or OBRs in PTC is associated with tumor size and may be a potential target in PTC. D.A. Spandidos 2013-03 2013-01-10 /pmc/articles/PMC3576217/ /pubmed/23425972 http://dx.doi.org/10.3892/ol.2013.1125 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	ZHANG, GUO-AN HOU, SEN HAN, SHA ZHOU, JIAN WANG, XU CUI, WEN
spellingShingle	ZHANG, GUO-AN HOU, SEN HAN, SHA ZHOU, JIAN WANG, XU CUI, WEN Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
author_facet	ZHANG, GUO-AN HOU, SEN HAN, SHA ZHOU, JIAN WANG, XU CUI, WEN
author_sort	ZHANG, GUO-AN
title	Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
title_short	Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
title_full	Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
title_fullStr	Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
title_full_unstemmed	Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
title_sort	clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
description	The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin and OBRs in 76 PTC samples using immunohistochemistry, and their associations with clinicopathological parameters were evaluated. The expression of OBRs was observed in the tumor cell membrane and/or cytoplasm, with a positive rate of 73.7% (56/76), while leptin was expressed in the tumor cell cytoplasm in 55 of 76 cases (72.4%). The expression of either protein was associated with greater tumor size (P=0.016 for leptin and P=0.002 for OBRs). In addition, the expression levels of leptin and OBRs were associated with each other. Neither leptin nor OBR expression levels were associated with other parameters, including age, body weight, postmenopausal state, multifocality and lymph node metastasis. These data suggest that the expression of leptin and/or OBRs in PTC is associated with tumor size and may be a potential target in PTC.
publisher	D.A. Spandidos
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576217/
_version_	1611956028961718272

Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer

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