A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

Zinc-finger nucleases (ZFNs) and TAL effector nucleases (TALENs) have been shown to induce targeted mutations, but they have not been extensively tested in any animal model. Here, we describe a large-scale comparison of ZFN and TALEN mutagenicity in zebrafish. Using deep sequencing, we found that TA...

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Bibliographic Details
Main Authors: Chen, Shijia, Oikonomou, Grigorios, Chiu, Cindy N., Niles, Brett J., Liu, Justin, Lee, Daniel A., Antoshechkin, Igor, Prober, David A.
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575824/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575824/

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