Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana

Sequential addition of segments in the posteriorly growing end of the embryo is a developmental mechanism common to many bilaterians. However, posterior growth and patterning in most animals also entails the establishment of a ‘posterior organiser’ that expresses the Caudal and Wnt proteins and has...

Full description

Bibliographic Details
Main Authors:	Chesebro, John E., Pueyo, Jose Ignacio, Couso, Juan Pablo
Format:	Online
Language:	English
Published:	The Company of Biologists 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575657/

id	pubmed-3575657
recordtype	oai_dc
spelling	pubmed-35756572013-02-21 Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana Chesebro, John E. Pueyo, Jose Ignacio Couso, Juan Pablo Research Article Sequential addition of segments in the posteriorly growing end of the embryo is a developmental mechanism common to many bilaterians. However, posterior growth and patterning in most animals also entails the establishment of a ‘posterior organiser’ that expresses the Caudal and Wnt proteins and has been proposed to be an ancestral feature of animal development. We have studied the functional relationships between the Wnt-driven organiser and the segmentation mechanisms in a basal insect, the cockroach Periplaneta americana. Here, posteriorly-expressed Wnt1 promotes caudal and Delta expression early in development to generate a growth zone from which segments will later bud off. caudal maintains the undifferentiated growth zone by dampening Delta expression, and hence Notch-mediated segmentation occurs just outside the caudal domain. In turn, Delta expression maintains Wnt1, maintaining this posterior gene network until all segments have formed. This feedback between caudal, Wnt and Notch-signalling in regulating growth and segmentation seems conserved in other arthropods, with some aspects found even in vertebrates. Thus our findings not only support an ancestral Wnt posterior organiser, but also impinge on the proposals for a common origin of segmentation in arthropods, annelids and vertebrates. The Company of Biologists 2012-12-19 /pmc/articles/PMC3575657/ /pubmed/23430316 http://dx.doi.org/10.1242/bio.20123699 Text en © 2012. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chesebro, John E. Pueyo, Jose Ignacio Couso, Juan Pablo
spellingShingle	Chesebro, John E. Pueyo, Jose Ignacio Couso, Juan Pablo Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
author_facet	Chesebro, John E. Pueyo, Jose Ignacio Couso, Juan Pablo
author_sort	Chesebro, John E.
title	Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
title_short	Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
title_full	Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
title_fullStr	Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
title_full_unstemmed	Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana
title_sort	interplay between a wnt-dependent organiser and the notch segmentation clock regulates posterior development in periplaneta americana
description	Sequential addition of segments in the posteriorly growing end of the embryo is a developmental mechanism common to many bilaterians. However, posterior growth and patterning in most animals also entails the establishment of a ‘posterior organiser’ that expresses the Caudal and Wnt proteins and has been proposed to be an ancestral feature of animal development. We have studied the functional relationships between the Wnt-driven organiser and the segmentation mechanisms in a basal insect, the cockroach Periplaneta americana. Here, posteriorly-expressed Wnt1 promotes caudal and Delta expression early in development to generate a growth zone from which segments will later bud off. caudal maintains the undifferentiated growth zone by dampening Delta expression, and hence Notch-mediated segmentation occurs just outside the caudal domain. In turn, Delta expression maintains Wnt1, maintaining this posterior gene network until all segments have formed. This feedback between caudal, Wnt and Notch-signalling in regulating growth and segmentation seems conserved in other arthropods, with some aspects found even in vertebrates. Thus our findings not only support an ancestral Wnt posterior organiser, but also impinge on the proposals for a common origin of segmentation in arthropods, annelids and vertebrates.
publisher	The Company of Biologists
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575657/
_version_	1611955918927298560

Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana

Similar Items