Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population

Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of consumer products and have been detected worldwide in human blood. Recent studies mainly of highly exposed populations have indicated that PFOA and PFOS may affect serum cholesterol levels, but the magnitude of t...

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Main Authors:	Eriksen, Kirsten T., Raaschou-Nielsen, Ole, McLaughlin, Joseph K., Lipworth, Loren, Tjønneland, Anne, Overvad, Kim, Sørensen, Mette
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575486/

id	pubmed-3575486
recordtype	oai_dc
spelling	pubmed-35754862013-02-25 Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population Eriksen, Kirsten T. Raaschou-Nielsen, Ole McLaughlin, Joseph K. Lipworth, Loren Tjønneland, Anne Overvad, Kim Sørensen, Mette Research Article Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of consumer products and have been detected worldwide in human blood. Recent studies mainly of highly exposed populations have indicated that PFOA and PFOS may affect serum cholesterol levels, but the magnitude of the effect may be inconsistent across exposure levels. The aim of the present cross-sectional study was to investigate the association between plasma PFOA and PFOS and total cholesterol in a general, middle-aged Danish population. The study population comprised 753 individuals (663 men and 90 women), 50–65 years of age, nested within a Danish cohort of 57,053 participants. Blood samples were taken from all cohort members at enrolment (1993–1997) and stored in a biobank at -150°C. Plasma levels of PFOA and PFOS and serum levels of total cholesterol were measured. The associations between plasma PFOA and PFOS levels and total cholesterol levels were analysed by generalized linear models, both crude and adjusted for potential confounders. We observed statistically significant positive associations between both perfluorinated compounds and total cholesterol, e.g. a 4.4 [95% CI = 1.1–7.8] higher concentration of total cholesterol (mg/dL) per interquartile range of PFOA plasma level. Sex and prevalent diabetes appeared to modify the association between PFOA and PFOS, respectively, and cholesterol. In conclusion, this study indicated positive associations between plasma PFOA and PFOS levels and total cholesterol in a middle-aged Danish population, although whether the observed pattern of results reflects a causal association is unclear. Public Library of Science 2013-02-18 /pmc/articles/PMC3575486/ /pubmed/23441227 http://dx.doi.org/10.1371/journal.pone.0056969 Text en © 2013 Eriksen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Eriksen, Kirsten T. Raaschou-Nielsen, Ole McLaughlin, Joseph K. Lipworth, Loren Tjønneland, Anne Overvad, Kim Sørensen, Mette
spellingShingle	Eriksen, Kirsten T. Raaschou-Nielsen, Ole McLaughlin, Joseph K. Lipworth, Loren Tjønneland, Anne Overvad, Kim Sørensen, Mette Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
author_facet	Eriksen, Kirsten T. Raaschou-Nielsen, Ole McLaughlin, Joseph K. Lipworth, Loren Tjønneland, Anne Overvad, Kim Sørensen, Mette
author_sort	Eriksen, Kirsten T.
title	Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
title_short	Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
title_full	Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
title_fullStr	Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
title_full_unstemmed	Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population
title_sort	association between plasma pfoa and pfos levels and total cholesterol in a middle-aged danish population
description	Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of consumer products and have been detected worldwide in human blood. Recent studies mainly of highly exposed populations have indicated that PFOA and PFOS may affect serum cholesterol levels, but the magnitude of the effect may be inconsistent across exposure levels. The aim of the present cross-sectional study was to investigate the association between plasma PFOA and PFOS and total cholesterol in a general, middle-aged Danish population. The study population comprised 753 individuals (663 men and 90 women), 50–65 years of age, nested within a Danish cohort of 57,053 participants. Blood samples were taken from all cohort members at enrolment (1993–1997) and stored in a biobank at -150°C. Plasma levels of PFOA and PFOS and serum levels of total cholesterol were measured. The associations between plasma PFOA and PFOS levels and total cholesterol levels were analysed by generalized linear models, both crude and adjusted for potential confounders. We observed statistically significant positive associations between both perfluorinated compounds and total cholesterol, e.g. a 4.4 [95% CI = 1.1–7.8] higher concentration of total cholesterol (mg/dL) per interquartile range of PFOA plasma level. Sex and prevalent diabetes appeared to modify the association between PFOA and PFOS, respectively, and cholesterol. In conclusion, this study indicated positive associations between plasma PFOA and PFOS levels and total cholesterol in a middle-aged Danish population, although whether the observed pattern of results reflects a causal association is unclear.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575486/
_version_	1611955851540561920

Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population

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