Pathogenic Mutation in VPS35 Impairs Its Protection against MPP+ Cytotoxicity
Parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. Both neuronal toxicants and genetic factors are suggested to be involved in the disease pathogenesis. The mitochondrial toxicant 1-methyl-4-phenylpyridinium (MPP+) shows a highly...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572397/ |