Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder

Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder

Socio-communicative impairments are salient features of autism spectrum disorder (ASD) from a young age. The anterior prefrontal cortex (aPFC), or Brodmann area 10, is a key processing area for social function, and atypical development of this area is thought to play a role in the social deficits in...

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Main Authors: Kikuchi, Mitsuru, Yoshimura, Yuko, Shitamichi, Kiyomi, Ueno, Sanae, Hiraishi, Hirotoshi, Munesue, Toshio, Hirosawa, Tetsu, Ono, Yasuki, Tsubokawa, Tsunehisa, Inoue, Yoshihiro, Oi, Manabu, Niida, Yo, Remijn, Gerard B., Takahashi, Tsutomu, Suzuki, Michio, Higashida, Haruhiro, Minabe, Yoshio
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571984/
id pubmed-3571984
recordtype oai_dc
spelling pubmed-35719842013-02-15 Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder Kikuchi, Mitsuru Yoshimura, Yuko Shitamichi, Kiyomi Ueno, Sanae Hiraishi, Hirotoshi Munesue, Toshio Hirosawa, Tetsu Ono, Yasuki Tsubokawa, Tsunehisa Inoue, Yoshihiro Oi, Manabu Niida, Yo Remijn, Gerard B. Takahashi, Tsutomu Suzuki, Michio Higashida, Haruhiro Minabe, Yoshio Research Article Socio-communicative impairments are salient features of autism spectrum disorder (ASD) from a young age. The anterior prefrontal cortex (aPFC), or Brodmann area 10, is a key processing area for social function, and atypical development of this area is thought to play a role in the social deficits in ASD. It is important to understand these brain functions in developing children with ASD. However, these brain functions have not yet been well described under conscious conditions in young children with ASD. In the present study, we focused on the brain hemodynamic functional connectivity between the right and the left aPFC in children with ASD and typically developing (TD) children and investigated whether there was a correlation between this connectivity and social ability. Brain hemodynamic fluctuations were measured non-invasively by near-infrared spectroscopy (NIRS) in 3- to 7-year-old children with ASD (n = 15) and gender- and age-matched TD children (n = 15). The functional connectivity between the right and the left aPFC was assessed by measuring the coherence for low-frequency spontaneous fluctuations (0.01 – 0.10 Hz) during a narrated picture-card show. Coherence analysis demonstrated that children with ASD had a significantly higher inter-hemispheric connectivity with 0.02-Hz fluctuations, whereas a power analysis did not demonstrate significant differences between the two groups in terms of low frequency fluctuations (0.01 – 0.10 Hz). This aberrant higher connectivity in children with ASD was positively correlated with the severity of social deficit, as scored with the Autism Diagnostic Observation Schedule. This is the first study to demonstrate aberrant brain functional connectivity between the right and the left aPFC under conscious conditions in young children with ASD. Public Library of Science 2013-02-13 /pmc/articles/PMC3571984/ /pubmed/23418517 http://dx.doi.org/10.1371/journal.pone.0056087 Text en © 2013 Kikuchi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kikuchi, Mitsuru
Yoshimura, Yuko
Shitamichi, Kiyomi
Ueno, Sanae
Hiraishi, Hirotoshi
Munesue, Toshio
Hirosawa, Tetsu
Ono, Yasuki
Tsubokawa, Tsunehisa
Inoue, Yoshihiro
Oi, Manabu
Niida, Yo
Remijn, Gerard B.
Takahashi, Tsutomu
Suzuki, Michio
Higashida, Haruhiro
Minabe, Yoshio
spellingShingle Kikuchi, Mitsuru
Yoshimura, Yuko
Shitamichi, Kiyomi
Ueno, Sanae
Hiraishi, Hirotoshi
Munesue, Toshio
Hirosawa, Tetsu
Ono, Yasuki
Tsubokawa, Tsunehisa
Inoue, Yoshihiro
Oi, Manabu
Niida, Yo
Remijn, Gerard B.
Takahashi, Tsutomu
Suzuki, Michio
Higashida, Haruhiro
Minabe, Yoshio
Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
author_facet Kikuchi, Mitsuru
Yoshimura, Yuko
Shitamichi, Kiyomi
Ueno, Sanae
Hiraishi, Hirotoshi
Munesue, Toshio
Hirosawa, Tetsu
Ono, Yasuki
Tsubokawa, Tsunehisa
Inoue, Yoshihiro
Oi, Manabu
Niida, Yo
Remijn, Gerard B.
Takahashi, Tsutomu
Suzuki, Michio
Higashida, Haruhiro
Minabe, Yoshio
author_sort Kikuchi, Mitsuru
title Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
title_short Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
title_full Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
title_fullStr Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
title_full_unstemmed Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder
title_sort anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder
description Socio-communicative impairments are salient features of autism spectrum disorder (ASD) from a young age. The anterior prefrontal cortex (aPFC), or Brodmann area 10, is a key processing area for social function, and atypical development of this area is thought to play a role in the social deficits in ASD. It is important to understand these brain functions in developing children with ASD. However, these brain functions have not yet been well described under conscious conditions in young children with ASD. In the present study, we focused on the brain hemodynamic functional connectivity between the right and the left aPFC in children with ASD and typically developing (TD) children and investigated whether there was a correlation between this connectivity and social ability. Brain hemodynamic fluctuations were measured non-invasively by near-infrared spectroscopy (NIRS) in 3- to 7-year-old children with ASD (n = 15) and gender- and age-matched TD children (n = 15). The functional connectivity between the right and the left aPFC was assessed by measuring the coherence for low-frequency spontaneous fluctuations (0.01 – 0.10 Hz) during a narrated picture-card show. Coherence analysis demonstrated that children with ASD had a significantly higher inter-hemispheric connectivity with 0.02-Hz fluctuations, whereas a power analysis did not demonstrate significant differences between the two groups in terms of low frequency fluctuations (0.01 – 0.10 Hz). This aberrant higher connectivity in children with ASD was positively correlated with the severity of social deficit, as scored with the Autism Diagnostic Observation Schedule. This is the first study to demonstrate aberrant brain functional connectivity between the right and the left aPFC under conscious conditions in young children with ASD.
publisher Public Library of Science
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571984/
_version_ 1611954737964384256

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