CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion

CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion

T cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies to the costimulatory receptors CD134 plus CD137 can program T cells responding to tolerogenic antigen to undergo expansion and effector T cell differe...

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Bibliographic Details
Main Authors: Rose, Marie-Clare St., Taylor, Roslyn A., Bandyopadhyay, Suman, Qui, Harry Z., Hagymasi, Adam T., Vella, Anthony T., Adler, Adam J.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742/

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