Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers

The aim of this study was to observe the efficacy of clarithromycin-based triple therapy for Helicobacter pylori (Hp)-infected duodenal ulcer when combined with different pH levels of gastric juices. A total of 160 patients with Hp-infected duodenal ulcers were randomly allocated into two groups. Pa...

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Main Authors:	FAN, HONG-YUN, WANG, JUAN, YAN, GUO-CHAO, HUO, XIAO-HUI, MU, LI-JUAN, CHU, JIAN-KUN, NIU, WEI-WEI, DUAN, ZHI-YING, MA, JIN-CHENG, WANG, JING, WANG, ZHI-YU
Format:	Online
Language:	English
Published:	D.A. Spandidos 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570246/

id	pubmed-3570246
recordtype	oai_dc
spelling	pubmed-35702462013-02-13 Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers FAN, HONG-YUN WANG, JUAN YAN, GUO-CHAO HUO, XIAO-HUI MU, LI-JUAN CHU, JIAN-KUN NIU, WEI-WEI DUAN, ZHI-YING MA, JIN-CHENG WANG, JING WANG, ZHI-YU Articles The aim of this study was to observe the efficacy of clarithromycin-based triple therapy for Helicobacter pylori (Hp)-infected duodenal ulcer when combined with different pH levels of gastric juices. A total of 160 patients with Hp-infected duodenal ulcers were randomly allocated into two groups. Patients in the treatment group (n=80) were administered a 20-mg dose of omeprazole twice daily for 1 week and then the treatment and control groups (n=80) received therapy for Hp infection and duodenal ulcers. We observed the ulcer healing stage, the content of anti-Hp IgA in gastric juice and the Hp eradication rate before and after proton pump inhibitor therapy in the two groups. Results revealed that the Hp eradication rate in the treatment group was 93% compared with 81% in the control group, and the difference was statistically significant (P<0.05). The ulcer healing rate in the treatment group was 93%, compared with 70% in the control group (P<0.05). A positive linear correlation was observed between gastric pH and the content of anti-Hp IgA in gastric juice (P<0.05). Increasing gastric pH prior to anti-Hp therapy may be beneficial to the eradication of Hp and for promoting the healing of duodenal ulcers. D.A. Spandidos 2013-03 2013-01-02 /pmc/articles/PMC3570246/ /pubmed/23408776 http://dx.doi.org/10.3892/etm.2013.880 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	FAN, HONG-YUN WANG, JUAN YAN, GUO-CHAO HUO, XIAO-HUI MU, LI-JUAN CHU, JIAN-KUN NIU, WEI-WEI DUAN, ZHI-YING MA, JIN-CHENG WANG, JING WANG, ZHI-YU
spellingShingle	FAN, HONG-YUN WANG, JUAN YAN, GUO-CHAO HUO, XIAO-HUI MU, LI-JUAN CHU, JIAN-KUN NIU, WEI-WEI DUAN, ZHI-YING MA, JIN-CHENG WANG, JING WANG, ZHI-YU Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
author_facet	FAN, HONG-YUN WANG, JUAN YAN, GUO-CHAO HUO, XIAO-HUI MU, LI-JUAN CHU, JIAN-KUN NIU, WEI-WEI DUAN, ZHI-YING MA, JIN-CHENG WANG, JING WANG, ZHI-YU
author_sort	FAN, HONG-YUN
title	Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
title_short	Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
title_full	Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
title_fullStr	Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
title_full_unstemmed	Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
title_sort	increasing gastric juice ph level prior to anti-helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers
description	The aim of this study was to observe the efficacy of clarithromycin-based triple therapy for Helicobacter pylori (Hp)-infected duodenal ulcer when combined with different pH levels of gastric juices. A total of 160 patients with Hp-infected duodenal ulcers were randomly allocated into two groups. Patients in the treatment group (n=80) were administered a 20-mg dose of omeprazole twice daily for 1 week and then the treatment and control groups (n=80) received therapy for Hp infection and duodenal ulcers. We observed the ulcer healing stage, the content of anti-Hp IgA in gastric juice and the Hp eradication rate before and after proton pump inhibitor therapy in the two groups. Results revealed that the Hp eradication rate in the treatment group was 93% compared with 81% in the control group, and the difference was statistically significant (P<0.05). The ulcer healing rate in the treatment group was 93%, compared with 70% in the control group (P<0.05). A positive linear correlation was observed between gastric pH and the content of anti-Hp IgA in gastric juice (P<0.05). Increasing gastric pH prior to anti-Hp therapy may be beneficial to the eradication of Hp and for promoting the healing of duodenal ulcers.
publisher	D.A. Spandidos
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570246/
_version_	1611954235236155392

Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers

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