Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages

Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages

Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F. tularensis infected macrophages results in decreased T cell proliferatio...

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Bibliographic Details
Main Authors: Woolard, Matthew D., Barrigan, Lydia M., Fuller, James R., Buntzman, Adam S., Bryan, Joshua, Manoil, Colin, Kawula, Thomas H., Frelinger, Jeffrey A.
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568750/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568750/

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