dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS...

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Bibliographic Details
Main Authors: Ikenaka, Kensuke, Kawai, Kaori, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Iguchi, Yohei, Kobayashi, Kyogo, Kimata, Tsubasa, Waza, Masahiro, Tanaka, Fumiaki, Mori, Ikue, Sobue, Gen
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567092/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567092/

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