An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells

An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells

Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5. We o...

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Bibliographic Details
Main Authors: Sousa, Mirta M. L., Zub, Kamila Anna, Aas, Per Arne, Hanssen-Bauer, Audun, Demirovic, Aida, Sarno, Antonio, Tian, Erming, Liabakk, Nina B., Slupphaug, Geir
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566207/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566207/

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