In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice
In mammals, γ-aminobutyric acid (GABA) transmission in the amygdala is particularly important for controlling levels of fear and anxiety. Most GABA synthesis in the brain is catalyzed in inhibitory neurons from ℒ-glutamic acid by the enzyme glutamic acid decarboxylase 67 (GAD67). In the current stud...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565763/ |