Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A

Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A

SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction as well as reactivation of silenced genes in cancer cells. Histone...

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Bibliographic Details
Main Authors: Tran, Huong Thi Thanh, Kim, Hee Nam, Lee, Il-Kwon, Nguyen-Pham, Thanh-Nhan, Ahn, Jae-Sook, Kim, Yeo-Kyeoung, Lee, Je-Jung, Park, Kyeong-Soo, Kook, Hoon, Kim, Hyeoung-Joon
Format: Online
Language:English
Published: The Korean Academy of Medical Sciences 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565135/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565135/

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